Subject‐level Detection of Focal Neurodegeneration Using Spatiotemporal Connectomics: Towards Atrophy Characterization in Preclinical Alzheimer's Disease
Sánchez C, Diez I, Bueichekú E, Kim C, Grothe M, Sanchez‐Juan P, Sepulcre J. Subject‐level Detection of Focal Neurodegeneration Using Spatiotemporal Connectomics: Towards Atrophy Characterization in Preclinical Alzheimer's Disease. Alzheimer's & Dementia 2024, 20: e093803. PMCID: PMC11713922, DOI: 10.1002/alz.093803.Peer-Reviewed Original ResearchAlzheimer's diseaseNeurodegenerative diseasesGraph-theory-based frameworkHealthy agingBrain atrophyVoxel-based morphometryGray matter measuresAtrophy phenotypeSingle-subject levelPreclinical Alzheimer's diseaseCognitively normal participantsT1 MRI scansDisease phenotypePhenotypic heterogeneityBrain mechanismsGraph theory approachLongitudinal MRI dataFocal neurodegenerationNormal participantsAtrophy patternsFollow-up timepointsGroups of subjectsPhenotypePreclinical ADStructural similaritySubject‐level Detection of Focal Neurodegeneration Using Spatiotemporal Connectomics: Towards Atrophy Characterization in Preclinical Alzheimer’s Disease
Sánchez C, Diez I, Bueichekú E, Kim C, Grothe M, Sanchez‐Juan P, Sepulcre J. Subject‐level Detection of Focal Neurodegeneration Using Spatiotemporal Connectomics: Towards Atrophy Characterization in Preclinical Alzheimer’s Disease. Alzheimer's & Dementia 2024, 20: e089064. PMCID: PMC11715297, DOI: 10.1002/alz.089064.Peer-Reviewed Original ResearchAlzheimer's diseaseNeurodegenerative diseasesGraph-theory-based frameworkHealthy agingBrain atrophyVoxel-based morphometryGray matter measuresAtrophy phenotypeSingle-subject levelPreclinical Alzheimer's diseaseCognitively normal participantsT1 MRI scansDisease phenotypePhenotypic heterogeneityBrain mechanismsGraph theory approachLongitudinal MRI dataFocal neurodegenerationNormal participantsAtrophy patternsFollow-up timepointsGroups of subjectsPhenotypePreclinical ADStructural similarity
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