Identification of the kinase STK25 as an upstream activator of LATS signaling
Lim S, Hermance N, Mudianto T, Mustaly H, Mauricio I, Vittoria M, Quinton R, Howell B, Cornils H, Manning A, Ganem N. Identification of the kinase STK25 as an upstream activator of LATS signaling. Nature Communications 2019, 10: 1547. PMID: 30948712, PMCID: PMC6449379, DOI: 10.1038/s41467-019-09597-w.Peer-Reviewed Original ResearchMeSH KeywordsCell LineCell ProliferationGene Expression Regulation, NeoplasticGenes, Tumor SuppressorHippo Signaling PathwayHumansIntracellular Signaling Peptides and ProteinsProtein Serine-Threonine KinasesSignal TransductionConceptsHippo signalingHippo pathwayHippo tumor suppressor pathwayTranscriptional co-activator YAPActivation loop phosphorylationCo-activator YAPCore pathway componentsYAP/TAZ activationTumor suppressor pathwayKey unresolved questionLoop phosphorylationHippo activationPhosphorylation eventsHydrophobic motifTissue homeostasisTAZ activationUpstream activatorKinase activatorPathway componentsSuppressor pathwaySTK25Human cancersFunctional inactivationCellular proliferationSignaling
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