Oncogenic BRAF induces whole-genome doubling through suppression of cytokinesis
Darp R, Vittoria M, Ganem N, Ceol C. Oncogenic BRAF induces whole-genome doubling through suppression of cytokinesis. Nature Communications 2022, 13: 4109. PMID: 35840569, PMCID: PMC9287415, DOI: 10.1038/s41467-022-31899-9.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell Line, TumorCytokinesisMelanomaMutationProto-Oncogene Proteins B-rafTetraploidyZebrafishConceptsWhole-genome doubling eventsWhole-genome doublingSuppression of cytokinesisOncogenic BRAFZebrafish melanoma modelLocalization of RhoAG1/S phaseG1/SMAPK pathway activityCytokinesis regulatorsInhibition of RhoACytokinesis failureGenomic configurationNascent tumor cellsCentriole amplificationDiploid cellsCell cycleCytokinesisSuch karyotypesS phaseTetraploid cellsNear-tetraploid karyotypePathway activityChromosomal gainsRhoAInactivation of the Hippo tumor suppressor pathway promotes melanoma
Vittoria M, Kingston N, Kotynkova K, Xia E, Hong R, Huang L, McDonald S, Tilston-Lunel A, Darp R, Campbell J, Lang D, Xu X, Ceol C, Varelas X, Ganem N. Inactivation of the Hippo tumor suppressor pathway promotes melanoma. Nature Communications 2022, 13: 3732. PMID: 35768444, PMCID: PMC9243107, DOI: 10.1038/s41467-022-31399-w.Peer-Reviewed Original Research
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