Whole-genome doubling in tissues and tumors
Vittoria M, Quinton R, Ganem N. Whole-genome doubling in tissues and tumors. Trends In Genetics 2023, 39: 954-967. PMID: 37714734, PMCID: PMC10840902, DOI: 10.1016/j.tig.2023.08.004.Peer-Reviewed Original ResearchConceptsCell divisionTetraploid cellsSpecific cellular functionsSomatic human cellsWhole-genome doubling eventsWhole-genome doublingSuccessive cell divisionsCellular functionsGenomic stateTetraploid stateCell transitionWGDHuman cellsChromosomal contentTherapeutic avenuesCellsDivisionGeneticsPhysiology
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